The emergence of the digital age has brought rapid and profound transformations to contemporary society, including in education. Higher education institutions are increasingly embracing technology and innovative learning methods, such as blended learning, which combines face-to-face and online courses. However, the effectiveness of hands-on learning, which requires practical experiences and individualized support, can be compromised by the massification of teaching and inflexible learning methods. This study evaluates the hybridization of practical work (PW) in the Biophysics module for students in the Life Sciences (LS) stream as a case study, grounded in a pedagogical design model. The approach, based on the ADDIE model, integrates online video capsules with face-to-face practical work to enhance learning. A multi-dimensional questionnaire, distributed to 421 students, revealed a majority level of satisfaction, attributed to access to online resources and individualized support. The study highlights the importance of a pedagogical scenario adapted to learners’ needs to ensure the success of this hybridization.