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Membrane technology provides solutions to a wide range of separation challenges encountered during the downstream processing of microbial fermentation broths. This chapter begins by briefly introducing the fundamental concepts of artificial membranes and explaining how they differ from biological membranes. It then explores the key principles of membrane separations, with a particular focus on mass transport phenomena. The discussion clearly highlights where membranes diverge from or excel in comparison to other unit operations. Furthermore, it addresses the critical membrane parameters that must be carefully considered to reliably evaluate membrane separation performance. Finally, examples of integrating membrane separations into the downstream processing of microbial fermentations are presented, illustrating how the diverse capabilities of membranes can be systematically leveraged.

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Membrane Separation and Purification in Downstream Processing: Novel Approaches to Classical Problems

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  • 发表日期：

    2026年

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  • Thomas Schäfer

摘要

Membrane technology provides solutions to a wide range of separation challenges encountered during the downstream processing of microbial fermentation broths. This chapter begins by briefly introducing the fundamental concepts of artificial membranes and explaining how they differ from biological membranes. It then explores the key principles of membrane separations, with a particular focus on mass transport phenomena. The discussion clearly highlights where membranes diverge from or excel in comparison to other unit operations. Furthermore, it addresses the critical membrane parameters that must be carefully considered to reliably evaluate membrane separation performance. Finally, examples of integrating membrane separations into the downstream processing of microbial fermentations are presented, illustrating how the diverse capabilities of membranes can be systematically leveraged.