This chapter presents the history and impact of pioneering women in defense and computing. Ada Lovelace is recognized for her early vision of computer programming, while Admiral Grace Hopper advanced programming languages and influenced modern computing. Margaret Hamilton led the development of reliable software for the Apollo missions. Elizabeth “Jake” Feinler created early internet naming conventions that shaped today’s digital infrastructure. The ENIAC Six—Kay McNulty, Betty Jennings, Betty Snyder, Marlyn Wescoff, Fran Bilas, and Ruth Lichterman—programmed one of the first electronic computers, transforming defense applications. Together, these women’s innovation and leadership shaped technology in defense and continue to inspire future generations.