The use of materials made from renewable raw materials opens interesting possibilities for substituting metal materials in machine tool design, particularly in lightweight design. Machine enclosures, for example, are components that can be made of sustainable materials. Particularly in the case of machine tools for machining wood and composite materials, the machine enclosure is often designed as a moving partial enclosure. It encloses the direct working space, protects against ejected parts, and reduces noise emissions as well as dust pollution. These properties ensure an extensive protection for the operator. However, the mass of the moving partial enclosure has an influence on the dynamic behaviour as well as the acceleration and braking processes of the machine. The use of lightweight materials made from renewable raw materials therefore shows great potential. The sandwich structure developed here allowed a reduction in the weight of machine enclosures compared with steel designs. Furthermore, the enclosures did not only fulfil protective functions but also improved the acoustic properties, as the propagation of sound emissions from the machine was reduced. A reduction in weight opens the possibility for further optimising the machine enclosure, for example, by reducing the open areas in the enclosure to improve the collection of chips and dust. By using wood-based materials in machine enclosures, it is possible to contribute to the ecological transformation of the industry and the manufacture of products. In addition, the carbon footprint can be reduced, making the machine enclosure a carbon neutral machine component.