Persistent organic pollutants, because of their persistent nature and ability to accumulate in living organisms, pose considerable risks to avian populations across the globe after multiple way entry into ecosystems via home, agricultural, and industrial sources. The article explains absorption, distribution, metabolism and excretion of POPs in birds, and highlights the biochemical and molecular means by which POPs interfere with immunological, reproductive, neurological and endocrine systems. The main mechanisms underlying immunotoxic effects are the interference with signalling pathways and cytokine generation. Biomagnification, the mechanism by which POP concentrations escalate at every trophic level and primarily effect predatory bird species such as raptors and seabirds is also examined. Such biomagnification exacerbates the toxic effects, leading to severe health effects like organ damage, immunosuppression, infertility, population declines, altered reproductive success, behavioural changes, and mortality in birds. High levels of PCBs and dioxins have been found in the tissues of albatrosses, gulls, and other seabirds. These avian toxicology studies also serve as crucial bioindicators of environmental health, providing insights into the broader ecological impacts of POPs.