Quitting smoking remains one of the most important actions a patient can take for their health—and one of the most difficult to achieve. This chapter provides a clear, compassionate approach to smoking cessation that goes beyond nicotine replacement and prescriptions. It explores the psychological grip of smoking, the identity tied to it, and the real reasons people struggle to quit. Using motivational interviewing and evidence-based counseling strategies, clinicians can meet patients where they are and support them through their journey to becoming smoke-free.