Vaccines remain one of the most effective tools in modern medicine—yet they have also become a common source for misinformation, conflict, and challenging conversations. This chapter focuses on how primary care clinicians can navigate vaccine hesitancy with empathy, evidence, and clarity. It offers practical strategies for addressing common concerns, correcting misinformation, and building trust through respectful dialogue. By focusing on communication rather than confrontation, clinicians can become effective advocates for vaccination while maintaining strong therapeutic relationships. Whether discussing routine childhood vaccines, the annual flu shot, or newer immunizations like those for COVID-19, this chapter equips clinicians to lead with both science and compassion.