The diagnosis and identification of parasite infections depend on numerous laboratory techniques. Advancements in new diagnostic instruments have created new paths for a great increase in parasite identification. Several more recent highly specific and sensitive serology-based assays such as the Falcon assay screening test ELISA (FAST-ELISA), Dot-ELISA, rapid antigen detection system (RDTS), and luciferase immunoprecipitation system (LIPS) have made it possible for researchers to increase the screening of samples with maximum accuracy. With higher specificity and sensitivity, molecular-based techniques as Luminex, real-time polymerase chain reaction, and loop-mediated isothermal amplification (LAMP) have great promise for use in parasite detection allowing researchers to answer deeper questions with more certainty than ever before. Proteomic technology has also been introduced for the identification of biomarkers employing tissues or biological fluids from the contaminated host enabling researchers to predict much of the disease burden before the disease becomes overt.