Imaging of the wrist and hand requires an integrated understanding of the complex anatomy of tendons, pulleys, ligaments, joints, and bones, together with the relative strengths and limitations of available modalities, particularly MRI and ultrasound. This chapter is divided into two main sections: wrist imaging and hand imaging. The wrist section reviews common fracture types, scaphoid avascular necrosis, carpal dislocations and instability, and associated ligament injuries. Pathologies responsible for ulnar-sided wrist pain, including triangular fibrocartilage complex tears, distal radioulnar joint pathology, and extensor carpi ulnaris tendon disease, are also addressed. Additional topics include tendon disorders and median nerve pathology. The second part of the chapter focuses on hand pathologies, including extensor and flexor tendon injuries, thumb carpometacarpal (TMC) and metacarpophalangeal (MCP) joint pathology, and common hand fractures. For each anatomical region, the relevant pathologies (traumatic, degenerative, and instability-related) are described, emphasizing characteristic imaging appearances on radiographs, CT, MRI, and ultrasound, as well as guidance on selecting the most appropriate modality.