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Obsessive-Compulsive Disorder (OCD) can be classified as a psychiatric condition which is characterised by persistent intrusive thoughts, to be called obsessions, and repetitive behaviours and mental acts, to be called compulsions. Recent studies have linked OCD to increased methylation of the oxytocin receptor (OXTR) gene which potentially impacts OCD-linked social and emotional behaviours. Options to treat OCD include cognitive-behavioural therapy (CBT) and selective serotonin reuptake inhibitors (SSRI). Challenges to these treatment options exist due to some individuals not responding well to SSRIs. The paper introduces a hypothetical treatment option to restore OXTR functionality. The research focuses on epigenetics in OCD and presents simulations involving DNA methylation changes. In the first presented scenario OCD development is shown triggered by childhood trauma. Scenario two introduces an epigenetic therapy to counteract the OCD symptoms by demethylating the OXTR gene. The simulated hypothetical therapy shows the potential to relieve OCD symptoms. Epigenetic drugs used in diseases like cancer, do indeed suggest potential for usage in other disorders like OCD.

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A Multi-Order Adaptive Network Analysis for DNA-Methylation Pathways, Action Regulation and the Development of OCD

  • 章节

  • 发表日期：

    2026年

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  • Lotte Huisman,
  • Catherine Ong,
  • Marco van de Werken,
  • Jan Treur

摘要

Obsessive-Compulsive Disorder (OCD) can be classified as a psychiatric condition which is characterised by persistent intrusive thoughts, to be called obsessions, and repetitive behaviours and mental acts, to be called compulsions. Recent studies have linked OCD to increased methylation of the oxytocin receptor (OXTR) gene which potentially impacts OCD-linked social and emotional behaviours. Options to treat OCD include cognitive-behavioural therapy (CBT) and selective serotonin reuptake inhibitors (SSRI). Challenges to these treatment options exist due to some individuals not responding well to SSRIs. The paper introduces a hypothetical treatment option to restore OXTR functionality. The research focuses on epigenetics in OCD and presents simulations involving DNA methylation changes. In the first presented scenario OCD development is shown triggered by childhood trauma. Scenario two introduces an epigenetic therapy to counteract the OCD symptoms by demethylating the OXTR gene. The simulated hypothetical therapy shows the potential to relieve OCD symptoms. Epigenetic drugs used in diseases like cancer, do indeed suggest potential for usage in other disorders like OCD.