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The Coat Protein I (COPI) complex forms both vesicles and tubules for transport at the Golgi complex. Anterograde Golgi transport occurs with the Golgi cisternae acting as carriers, a process known as cisternal maturation, while COPI vesicles transport in the retrograde direction. The cargoes of retrograde transport include Golgi glycosylation enzymes, enabling these enzymes to maintain their distributions as residents of the cis, medial, and trans cisternae of the Golgi. COPI also forms tubules that connect the Golgi cisternae, which enables a faster mode of anterograde Golgi transport than that mediated by cisternal maturation. Recent advancements in our understanding of COPI vesicle formation have significantly contributed to the current view of Golgi transport. Particularly, the discovery of COPI tubules has provided new insights into how Golgi transport occurs.

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COPI Vesicle and Tubule Formation at the Golgi Complex

  • 章节

  • 发表日期：

    2026年

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  • Kunyou Park,
  • Jia-Shu Yang,
  • Victor W. Hsu,
  • Seung-Yeol Park

摘要

The Coat Protein I (COPI) complex forms both vesicles and tubules for transport at the Golgi complex. Anterograde Golgi transport occurs with the Golgi cisternae acting as carriers, a process known as cisternal maturation, while COPI vesicles transport in the retrograde direction. The cargoes of retrograde transport include Golgi glycosylation enzymes, enabling these enzymes to maintain their distributions as residents of the cis, medial, and trans cisternae of the Golgi. COPI also forms tubules that connect the Golgi cisternae, which enables a faster mode of anterograde Golgi transport than that mediated by cisternal maturation. Recent advancements in our understanding of COPI vesicle formation have significantly contributed to the current view of Golgi transport. Particularly, the discovery of COPI tubules has provided new insights into how Golgi transport occurs.