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The Golgi apparatus is a crucial organelle that is involved in various cellular processes, including cellular secretion, and is primarily responsible for the modification, sorting, and transport of proteins and lipids. However, recently, we discovered a novel Golgi function, namely, Golgi membrane-associated degradation (GOMED). GOMED is a cellular function in which the trans-Golgi membrane undergoes deformation and becomes spherical, breaking down proteins and lipids that have been internalized. This process is conserved from yeast to mammalian cells. GOMED primarily plays a role in the quality control of hormones, cytokines, and cell membrane receptors that pass through the Golgi apparatus, and is crucial for maintaining the normal function of pancreatic β cell, neurons, and intestinal epithelial cells. Therefore, abnormalities in GOMED can lead to neurodegenerative diseases and inflammatory bowel diseases.

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Golgi Membrane-Associated Degradation (GOMED), a New Intracellular Proteolysis Mechanism

  • 章节

  • 发表日期：

    2026年

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  • Shigeomi Shimizu,
  • Shinya Honda,
  • Satoru Torii,
  • Satoko Arakawa,
  • Masatsune Tsujioka,
  • Hirofumi Yamaguchi,
  • Hajime Tajima Sakurai

摘要

The Golgi apparatus is a crucial organelle that is involved in various cellular processes, including cellular secretion, and is primarily responsible for the modification, sorting, and transport of proteins and lipids. However, recently, we discovered a novel Golgi function, namely, Golgi membrane-associated degradation (GOMED). GOMED is a cellular function in which the trans-Golgi membrane undergoes deformation and becomes spherical, breaking down proteins and lipids that have been internalized. This process is conserved from yeast to mammalian cells. GOMED primarily plays a role in the quality control of hormones, cytokines, and cell membrane receptors that pass through the Golgi apparatus, and is crucial for maintaining the normal function of pancreatic β cell, neurons, and intestinal epithelial cells. Therefore, abnormalities in GOMED can lead to neurodegenerative diseases and inflammatory bowel diseases.