Among European countries, Italy is one of those that has the largest number of historical buildings. To preserve the building heritage, large areas are subjected to both urban and environmental restrictions. While protecting the social landscape, these pose significant challenges when it comes to retrofit existing structures of historic value. Thus, to improve their structural and energetic behavior while maintaining the original functionality and aesthetic, low-damage and low-impact interventions are needed. Moreover, many historical and existing masonry buildings, in Italy, serves as schools and hospitals. This article discusses the applications of an innovative strengthening system consisting of lightweight cold-formed steel net (also similar to an exoskeleton), dry-anchored to the building façade with the possibility to be embedded in a thermal coat. Two applicative cases to existing school buildings are presented, both located in the mountains of Modena (Italy), composed by: (i) stones and clay bricks and (ii) stones. Additionally, a short overview of the application of the same retrofit system on mixed bricks-stone masonry nursing home located in central Italy is shown. In-situ installation of the retrofitting system allowed for minor disturbance to the occupants, preserving the operability of the buildings during installation phases. Comparison between as-built and retrofitted conditions are provided in terms of both seismic and thermal classification, in accordance with Italian Standards. These real-cases showed how combined seismic and thermal improvements can be obtained by using this low-impact retrofitting system, which has resulted compatible to application on existing unreinforced masonry buildings.