Artificial intelligence (AI) is revolutionizing podcasts in medical education, offering new ways to streamline content creation, enhance accessibility, and improve engagement. This chapter explores AI’s role in script writing, post-podcast production notes, translation, and discusses the rise of AI-generated podcasts. We examine current applications, compare AI-created podcasts to traditional ones, and provide a comprehensive step-by-step guide on how to create AI-generated podcasts, integrating recent research findings and advanced AI tools.