Municipal solid waste management (MSWM) controls the generation, collection, storage, transfer, transport, processing, and disposal of solid waste. The increasing importance of MSWM in recent years is vulnerable to a growing population, dense-urban areas, cultural differences, changing lifestyles, and food habits. The study presents the South Asian context of MSWM, related problems, and potential solutions. This study used a comprehensive analysis of the quality of MSW and its issues in South Asia (Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka). The study is discussed in six sections. This study clears the picture of the appropriate implications; an effective MSWM is a long-term goal: adequate infrastructure, a proper waste transportation system, and scientific waste treatment. Financial support, advanced recycling techniques, and proper waste-to-energy (WtE). Involvement of private-public partnerships, self-help groups, and non-government organizations for the successful MSWM in South Asia.