The synthesis of missing MRI modalities has emerged as a critical solution to address incomplete multi-parametric imaging in brain tumor diagnosis and treatment planning. While recent advances in generative models, especially GANs and diffusion-based approaches, have demonstrated promising results in cross-modality MRI generation, challenges remain in preserving anatomical fidelity and minimizing synthesis artifacts. In this work, we build upon the Hybrid Fusion GAN (HF-GAN) framework, introducing several enhancements aimed at improving synthesis quality and generalization across tumor types. Specifically, we incorporate z-score normalization, optimize network components for faster and more stable training, and extend the pipeline to support multi-view generation across various brain tumor categories, including gliomas, metastases, and meningiomas. Our approach focuses on refining 2D slice-based generation to ensure intra-slice coherence and reduce intensity inconsistencies, ultimately supporting more accurate and robust tumor segmentation in scenarios with missing imaging modalities. Our source code is available at https://github.com/AImageLab-zip/BraSyn25 .

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No More Slice Wars: Towards Harmonized Brain MRI Synthesis for the BraSyn Challenge

  • Omar Carpentiero,
  • Kevin Marchesini,
  • Costantino Grana,
  • Federico Bolelli

摘要

The synthesis of missing MRI modalities has emerged as a critical solution to address incomplete multi-parametric imaging in brain tumor diagnosis and treatment planning. While recent advances in generative models, especially GANs and diffusion-based approaches, have demonstrated promising results in cross-modality MRI generation, challenges remain in preserving anatomical fidelity and minimizing synthesis artifacts. In this work, we build upon the Hybrid Fusion GAN (HF-GAN) framework, introducing several enhancements aimed at improving synthesis quality and generalization across tumor types. Specifically, we incorporate z-score normalization, optimize network components for faster and more stable training, and extend the pipeline to support multi-view generation across various brain tumor categories, including gliomas, metastases, and meningiomas. Our approach focuses on refining 2D slice-based generation to ensure intra-slice coherence and reduce intensity inconsistencies, ultimately supporting more accurate and robust tumor segmentation in scenarios with missing imaging modalities. Our source code is available at https://github.com/AImageLab-zip/BraSyn25 .