Unified Brain MRI Synthesis with Mixture of Multimodal Hierarchical VAEs (BraSyn 2025)
摘要
Unified synthesis of missing MRI sequences facilitates robust image analysis in brain tumor patients when imaging data are incomplete. We present a unified framework based on the Mixture of Multimodal Hierarchical Variational Autoencoders (MMHVAE), which performs cross-modal MRI synthesis with arbitrary missing sequences. MMHVAE leverages a hierarchical latent representation and a mixture of unimodal posteriors to flexibly model incomplete inputs. For the MICCAI 2025 BraSyn challenge, our approach synthesizes one randomly missing sequence from the remaining three, while addressing inter-center acquisition variability through contrast harmonization. On the BraSyn validation set, the method achieves high-quality synthesis with Structural Similarity Index Measures (SSIM) exceeding \(99.7\%\) in tumor regions and promising Dice scores in downstream tumor segmentation tasks. These results demonstrate the potential of MMHVAE as a unified solution for brain MRI synthesis in the presence of missing sequences.