Integrate bioremediation into the sustainable agriculture systems for innovation in mitigating environmental pollution and enhancing agricultural productivity. This is mainly with respect to the challenges brought by climate variability. Bioremediation harnesses microorganisms, fungi, and plants to metabolically degrade, detoxify, or immobilize heavy metals and organic contaminants such as pesticides, thereby restoring the quality of soil and water. Within the context of delta regions, where agriculture is highly vulnerable to salinity intrusion, flooding, and pollutant accumulation, bioremediation emerges as a vital strategy to strengthen delta resilience by maintaining ecosystem balance and securing long-term agricultural sustainability. This chapter discusses the mechanisms, applications, and potential of bioremediation strategies in agricultural systems, focusing on the role that bioremediation plays in addressing soil and water contamination while promoting crop health and productivity. It further examines the synergy between bioremediation and geospatial technologies, which enable precise monitoring and management of contaminated sites. Case studies and examples are provided to illustrate successful bioremediation practices that support sustainable agricultural development. The chapter concludes by summarizing the challenges, limitations, and future prospects of integrating bioremediation into climate-resilient agriculture systems, underlining its importance in attaining global food security, environmental sustainability, and the resilience of vulnerable delta systems.