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Atherosclerosis is a chronic inflammatory disease that can lead to heart attacks and strokes. Atherosclerotic plaques form in the walls of large arteries. Initially their growth is driven by modified low density lipoproteins, immune cells and inflammatory cytokines. As the plaque matures, smooth muscle cells and necrotic material become important constituents, and as it grows, the plaque starts to distort the artery wall. Modelling has started to address many of these phenomena, but is hampered by difficulties collecting, interpreting and fitting data. In this article we reflect on the enterprise of modelling atherosclerotic plaques, progress so far, what now needs to be done and its relation to cognate areas of mathematical modelling, particularly cancer and wound healing.

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Atherosclerosis: reflections on mathematical modelling, data and other matters

  • 章节

  • 发表日期：

    2026年

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  • Keith L. Chambers,
  • Adelle C. F. Coster,
  • Jennifer A. Flegg,
  • Ryan J. Murphy,
  • Mary R. Myerscough,
  • Joseph P. Ndenda,
  • Jichao Pan,
  • Michael G. Watson

摘要

Atherosclerosis is a chronic inflammatory disease that can lead to heart attacks and strokes. Atherosclerotic plaques form in the walls of large arteries. Initially their growth is driven by modified low density lipoproteins, immune cells and inflammatory cytokines. As the plaque matures, smooth muscle cells and necrotic material become important constituents, and as it grows, the plaque starts to distort the artery wall. Modelling has started to address many of these phenomena, but is hampered by difficulties collecting, interpreting and fitting data. In this article we reflect on the enterprise of modelling atherosclerotic plaques, progress so far, what now needs to be done and its relation to cognate areas of mathematical modelling, particularly cancer and wound healing.