Technological advancements, particularly in artificial intelligence (AI), have revolutionized numerous industries, including aviation. This chapter explores the critical role of AI-powered passenger demand forecasting and its financial implications for airline companies. Accurate demand forecasting is essential for efficient capacity planning, route development, and overall operational management, directly influencing airline profitability and sustainability. The aviation sector’s increasing reliance on digital transformation—known as Aviation 4.0—integrates big data analytics, machine learning, and automation, enabling more precise and dynamic prediction models. These innovations not only improve operational efficiency and passenger experience but also mitigate financial risks associated with fluctuating demand, especially in a post-pandemic context marked by uncertainty and changing consumer behavior. Through a qualitative analysis, this chapter highlights how AI-driven forecasting tools empower airlines to optimize resource allocation, enhance strategic decision-making, and strengthen their competitive position in a rapidly evolving market. The findings underscore the importance of embracing AI technologies to ensure financial resilience and sustainable growth in the modern aviation industry.