The aim of this chapter is not to answer a question of a physical or metaphysical nature: “what is space?”, but to focus on a pragmatic problem:”when do we interpret space?”. In its three dimensions (the body, the thing, the social), space becomes interpretable when it has lost its usual bearings, when we are faced with phenomena of disorientation, when we are faced with unknown, strange spaces. Unlike a hermeneutic of space which focuses on the scholarly technologies of deciphering signs, this contribution gives priority to an anthropology interpretative of spatiality which highlights ordinary technologies of revealing meaning.While a hermeneutics of space draws its model from the text, the chapter adds an interpretative analysis of a shifting spatiality, irreducible to any inscription as a lastingly fixed expression. In place of a scholarly hermeneutic of space, we substitute a pragmatist hermeneutic of spatiality. It remains to be shown, first, that the text is not necessarily the best medium for thinking analogically about the problem of space; second, that not every relationship to space is necessarily subject to interpretation; and thirdly, that the problem of space is given in differentiated and entangled regimes of spatiality.