The paper considers the possibilities of creating effectively operating cyber-physical systems. The features of cyber-physical system management are studied from the point of view of rational use of the indicators describing it. The analysis of the possibilities of using the expert assessment method, in which the process of paired comparison of indicators is carried out, is carried out. It is proposed to use a scale in order to rank the analyzed indicators. A mathematical model is developed in order to optimize the information resources used when the required set of indicators is selected that must be taken into account. The formation of a multi-channel system is substantiated. The rationale for constructing prognostic models in a cyber-physical system when forming information resources is given, which made it possible to significantly refine the model. The results of identifying the required indicators, optimizing resources are presented, which made it possible to increase the efficiency of the cyber-physical system.