The global rise in waste generation poses serious environmental and economic challenges, necessitating innovative and sustainable wasteSustainable waste technologies management strategies to reduce greenhouse gas emissions, lessen dependence on landfills, and create sustainable waste managementWaste management strategies to reduce greenhouse gas emissions, lessen reliance valorisation has emerged as an auspicious strategy for converting complex and homogeneous waste streams, such as lignocellulosic agro-waste, industrial byproducts, and organic municipal solid waste, into value-added bioproducts, including biofuels, biopolymers, and bio-based fertilizersBio-based fertilizers valorization has materialized as an auspicious strategy for converting complex and homogenous waste streams like lignocellulosic agro-waste, industrial byproducts, and the organic municipal solid waste into value-added bioproducts, including biofuels, biopolymers, and bio-based fertilizersBio-based fertilizers it presents emerging advances in synthetic biology, microbial fuel cells (MFCs), and genetic engineering to enhance the use of hybrid omics technologies combined with artificial intelligence (AI) analytics as a modern tool for addressing the challenges of microbial valorization waste valorizationWaste valorization products that can be used to generate the use of hybrid omics technologies combined with artificial intelligence (AI) analytics as a modern tool for addressing the challenges of microbial valorization the use of hybrid omics technologies combined with artificial intelligence (AI) analytics as a modern tool for addressing the challenges waste valorisationWaste valorization products that can be used to generate the use of hybrid omics technologies combined with artificial intelligence (AI) analytics as a modern tool for addressing the challenges waste valorisationWaste valorization products that can be used to generate the use of hybrid omics technologies combined with artificial intelligence (AI) analytics as a modern tool for addressing the challenges stainable value from waste materials. Addressing these challenges contributes to achieve several Sustainable DevelopmentSustainable development GoalsSustainable Development Goals (SDGs) (SDGs), including Goals 2, 7, 12, 13, and 15. Microbial valorizationMicrobial valorization has emerged as an auspicious strategy for converting complex and homogeneous waste streams, such as lignocellulosic agro-waste, industrial byproducts, and organic municipal solid waste, into value-added bioproducts, including biofuels, biopolymers, and bio-based fertilizers. This chapter aims to systematically examine microbial bioconversionMicrobial bioconversion technologies, focusing on key mechanisms such as aerobic catabolism, anaerobic digestionAnaerobic digestion, fermentationFermentation, and landfilling. It explores microbial valorizationMicrobial valorization challenges that limit its scalability and industrial implementation. In addition, it presents emerging advances in synthetic biology, microbial fuel cells (MFCs), and genetic engineering to enhance bioconversion efficiency. This work also demonstrates the use of hybrid omics technologies combined with artificial intelligence (AI) analytics as a modern tool for addressing the challenges of microbial valorizationMicrobial valorization. Finally, the chapter outlines waste valorizationWaste valorization products that can be used to generate renewable energy resourcesRenewable energy resource to achieve global sustainabilitySustainability goals.