The effectiveness of the Electrokinetic remediation (EKR) technique for treating Cr (VI), Pb, and Cd-contaminated soils was investigated. Further, a Human Health Risk Assessment (HHRA) was performed using the USEPA methodology to investigate the reduction in health risks post-EKR. The best removal efficiency was achieved for Cr (VI) (77%), followed by Pb (65%) and Cd (30%). The synergistic interplay of CrO4− and Cr[EDTA]− complexes towards the anode resulted in higher removal than Pb, where the antagonistic action of Pb2+/Cd2+ and Pb[EDTA]−/Cd[EDTA]− complexes counteracted the movement, resulting in low net electromigration. The results from the HHRA indicated a significant reduction in the non-carcinogenic adverse effects from very high category to low and medium in adults and children, respectively. Carcinogenic risk, on the other hand, could not be reduced below the acceptable range of 10–6 after treatment but reduced from one in a hundred to one in thousand (10–3). The carcinogenic risks are expected to decrease further by increasing treatment time. The findings from this study concluded that EKR has the potential to reduce metal toxicity in soils. The results from risk assessment can be useful in forming risk-based management strategies for contaminated sites.