The aim of this research is to offer a research agenda that seeks to develop an enhanced teaching model of entrepreneurship, using Artificial Intelligence (AI), to foster the student’s sustainability entrepreneurialism mindset. Drawing a recent literature dealing with entrepreneurship education, pedagogy, AI and sustainability, it seems interesting to explore the outcomes of the integration of AI in the teaching methods on the students’ entrepreneurial skills, intention, innovation, opportunity recognition, and action from a sustainability perspective. The originality of the research is to offer an effective research agenda from an ontological perspective, that is, toward fostering the use of AI in entrepreneurship teaching methods to develop sustainable entrepreneurialism among the students from multi-paradigmatic dimensions: the individual as a set of traits and skills and the entrepreneurial process, from the stage of inspiration and ideation to the one of effective entrepreneurial action. The research is toward responding to a crucial question for the community of entrepreneurship instructors, trainers, and coaches regarding the way of how offering curricular and extracurricular programs and courses that are effective in terms of entrepreneurial action, from a sustainability point of view, among students in higher education, notably in Oman and the other GCC countries. It has fruitful practical implications for universities to foster the student’s sustainability, innovativeness, and entrepreneurialism. It also offers, a research agenda to draw the attention of the community of researchers to adopt the research action approach using mixed and experimental methodology that may be adequate to bring empirical validation through three stages: Teaching model conception, programs, pedagogical tool experimentation and results analysis.