The increasing prevalence of dietary supplements and weight loss products highlights the importance of understanding their interactions with medications. The rise of consumer reliance on these products, combined with their less stringent regulation by the Food and Drug Administration (FDA), poses potential risks of adverse drug-diet interactions. Over 50,000 dietary supplements are registered, with a significant portion consumed by older adults, raising concerns about toxicity and interactions leading to emergency room visits. A case study illustrates cerebrovascular complications linked to excessive caffeine intake from a weight loss supplement. The industry’s marketing strategies often promote health benefits without adequate clinical evidence. This underscores the need for healthcare professionals to educate patients about potential interactions, which may exacerbate medication side effects. Ongoing research is crucial to establish clearer guidelines and safeguards to protect consumers in the increasingly complex landscape of dietary supplements and medications.