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Background and aim: This study examined the status of serum iron biomarkers (iron, ferritin, and hepcidin) and their association with antiepileptic drugs in subjects with epilepsy. Methods: This study comprised 60 epileptic patients and 40 healthy controls recruited from the epilepsy clinics and neurology department in Prince Faisal bin Alhussein Hospital, Zarqa, Jordan. Clinical and biomedical data were collected by standard techniques. Serum levels of iron and ferritin were determined by chemistry autoanalyzer. Hepcidin levels were determined using ELISA technique. Results: Epileptic patients had significantly higher levels of Hb, MCV and ferritin than controls (p < 0.05). The levels of serum iron and hepcidin however, were significantly lower than controls (p < 0.05). In the patient’s group, hepcidin levels correlated negatively with ferritin (r = −0.395; p = 0.002) and with Hb (r = −0.275; 0.037). No significant correlation with iron was shown (r = −0.106; P = 0.434). Patients on sodium valproate had significantly higher mean levels of ferritin (135.5 ± 109.1 vs 94.1 ± 108.5 ng/ml; p = 0.041) and hepcidin (72.0 ± 14.6 vs 64.8 ± 10.5 ng/ml; p = 0.046) than patients on carbamazepine, respectively. The mean levels of hepcidin were significantly lower in patients with duration of drug intake >10 years than patients with duration of drug intake <10 years (63.4 ± 13.8 vs 70.8 ± 15.2 ng/ml; p = 0.05; respectively). On the contrary, the mean levels of ferritin were significantly higher in patients with duration of drug intake >10 years than patients with duration of drug intake <10 years (141.1 ± 134.2 vs 76.3 ± 71.5, p = 0.027; respectively). The mean levels of serum iron were significantly higher in males than in females (17.4 ± 9.2 vs 11.5 ± 3.9, p = 0.001; respectively). Conclusions: Results of the study indicate that iron status is altered in epileptic patients. Iron biomarkers are influenced by duration of drug intake, type of AED taken and by gender. A chronic inflammatory condition is likely to be associated with altered iron metabolism in epileptic subjects.

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A Study on the Status of Hepcidin and Iron Store in Patients on Antiepileptic Drugs

  • 章节

  • 发表日期：

    2026年

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  • Ola Qushtom,
  • Samir Awadallah

摘要

Background and aim: This study examined the status of serum iron biomarkers (iron, ferritin, and hepcidin) and their association with antiepileptic drugs in subjects with epilepsy. Methods: This study comprised 60 epileptic patients and 40 healthy controls recruited from the epilepsy clinics and neurology department in Prince Faisal bin Alhussein Hospital, Zarqa, Jordan. Clinical and biomedical data were collected by standard techniques. Serum levels of iron and ferritin were determined by chemistry autoanalyzer. Hepcidin levels were determined using ELISA technique. Results: Epileptic patients had significantly higher levels of Hb, MCV and ferritin than controls (p < 0.05). The levels of serum iron and hepcidin however, were significantly lower than controls (p < 0.05). In the patient’s group, hepcidin levels correlated negatively with ferritin (r = −0.395; p = 0.002) and with Hb (r = −0.275; 0.037). No significant correlation with iron was shown (r = −0.106; P = 0.434). Patients on sodium valproate had significantly higher mean levels of ferritin (135.5 ± 109.1 vs 94.1 ± 108.5 ng/ml; p = 0.041) and hepcidin (72.0 ± 14.6 vs 64.8 ± 10.5 ng/ml; p = 0.046) than patients on carbamazepine, respectively. The mean levels of hepcidin were significantly lower in patients with duration of drug intake >10 years than patients with duration of drug intake <10 years (63.4 ± 13.8 vs 70.8 ± 15.2 ng/ml; p = 0.05; respectively). On the contrary, the mean levels of ferritin were significantly higher in patients with duration of drug intake >10 years than patients with duration of drug intake <10 years (141.1 ± 134.2 vs 76.3 ± 71.5, p = 0.027; respectively). The mean levels of serum iron were significantly higher in males than in females (17.4 ± 9.2 vs 11.5 ± 3.9, p = 0.001; respectively). Conclusions: Results of the study indicate that iron status is altered in epileptic patients. Iron biomarkers are influenced by duration of drug intake, type of AED taken and by gender. A chronic inflammatory condition is likely to be associated with altered iron metabolism in epileptic subjects.