Generally, the energy drains of a virus infection on plants do not immediately cause much loss, as there is no “feverish” state at the onset of the disease. But in the end, just as with human diseases, there can be substantial effects on overall health, which for plants is often expressed in yield. Yet, what is many times just as (or even more) problematic for the grower and gardener, and the consumer, is the loss of quality due to induction of symptoms that cause malformations, stunting and discolorations on the plant or its produce, or even death of some plant tissues. Furthermore, since sanitation laws aim to prevent international distribution of infected plant material, even minimal negative effects may become obstacles for global commercial trade. Therefore, combined with the above-mentioned direct yield losses, growers also aim to avoid virus infections because of the negative economic impact by virus symptoms.