The application of artificial intelligence in dermatology, particularly through machine learning and deep learning, offers significant advancements in the diagnosis and treatment of skin conditions. However, the rapid development of AI technologies poses legal and regulatory challenges, especially concerning patient harm and liability. This chapter addresses the evolution of AI in dermatology, focusing on regulatory frameworks, liability issues, and case studies. It highlights the need for comprehensive legislation and harmonization of liability rules to ensure patient safety and foster innovation in healthcare AI. The chapter underscores the importance of collaboration among stakeholders to create a unified legal framework that keeps pace with technological advancements.