Endocrine-disrupting chemicals (EDCs) interfere with nuclear hormone receptors (NHRs) and alter hormonal balance, posing a serious risk to human and environmental health. Hydrophobicity and functional groups are two examples of the physicochemical characteristics that determine their persistence, bioaccumulation, and biomagnification. A number of remediation techniques have been investigated to lessen EDCs pollution, including physical, chemical, and biological methods. This study underscores the importance of integrated chemical, biological, and nanotechnological approaches for effective EDCs remediation. Chemically advanced oxidation processes, particularly ozonation and photocatalysis using ZnO and TiO₂-based nanomaterials, have proven effective in degrading persistent EDCs. Additionally, hybrid methods, such as Fenton-based reactions and LED-assisted photo-Fenton techniques, have shown promising results in wastewater treatment. Bacterial strains such as Pseudomonas putida and Bacillus sp. exhibit high EDCs degradation potential, while phytoremediation using species like Lemna minor and Brassica juncea is also used in the removal of EDCs. Despite advancements in these technologies, challenges remain in achieving complete EDCs removal due to their persistence and complex environmental interactions. Future research should focus on optimizing these methods for large-scale applications while ensuring cost-effectiveness and sustainability. Strengthening regulatory frameworks and advancing remediation technologies are crucial to mitigating the long-term impact of EDCs on ecosystems and human health.