Post-COVID 19 Neurological Syndrome (PCNS) has emerged as one of the most pressing global neurological challenges of the twenty first century. Affecting millions of people across all age groups and regions, PCNS presents with a wide range of persistent neurological symptoms including cognitive dysfunction, headache, fatigue, autonomic disturbances, mood disorders, and sensorimotor complaints. The syndrome is now recognized as a major contributor to disability, particularly in working age populations and women, and is beginning to shape the global burden of neurological disease in both high and low resource settings. This chapter provides a comprehensive overview of the global impact of PCNS, with special attention to low- and middle-income countries where the syndromic burden is often underestimated and poorly managed. We examine epidemiological trends, economic costs, social consequences, and health system gaps. Drawing on lessons from past neuroinfections, we highlight the urgent need for global surveillance, inclusive research, health workforce training, and integrated care models. PCNS is not only a medical condition but a public health priority. Addressing it effectively will require international cooperation, community engagement, and alignment with global brain health strategies.