The G2E project addresses the challenge of integrating circular economy principles into construction by developing eco-efficient gypsum plasters using recycled plasterboard waste. Aligning with the European Green Deal, the project aims to reduce landfill dependency and natural resource consumption by valorising gypsum and cellulose fibres in sustainable building materials. Key objectives include optimising recycling processes, adapting industrial equipment for efficient material integration, and designing formulations that meet performance and sustainability criteria. A structured framework was developed to guide waste valorisation, incorporating eco-design principles and lifecycle thinking from product development stages. The methodology defines technical specifications, adapts industrial processes, and assesses environmental impacts through Life Cycle Assessment. The project identifies key challenges, such as ensuring material purity, market acceptance, and industrial feasibility. Solutions include fostering collaboration between the construction and waste management sectors, establishing new value chains, and promoting eco-innovative materials for building envelopes. Circular production models focus on reducing calcination energy, improving coating durability, and enhancing by-product valorisation. Gypsum’s lower embedded carbon is ideal for Europe’s 2050 climate goals and the Renovation Wave initiative compared to other binders. This work highlights the transformative potential of recycled gypsum plasters in promoting sustainable construction and resilient built environments. By advancing waste valorisation technologies and integrating circularity into industrial practices, the project contributes to the transition towards a low-carbon construction industry.