This study presents experimental research on the feasibility of using waste products from various industrial sectors for the development of organomineral mixtures intended for constructing road bases for motor roads. The materials considered include milled asphalt concrete, oil sludge, technical hydrolysis lignin, and lime-containing waste (fine-milled sludge waste). The physical and mechanical properties of these materials were examined, and optimal ratios of each component within the mixture were determined. Each component contributes to forming a durable framework, increasing density, water resistance, adhesion, and cohesion properties, thereby enhancing strength and resistance to crack formation. A comparative analysis of the produced samples confirmed their compliance with established strength standards. Tests for rutting resistance demonstrated that the developed organomineral mixtures meet regulatory requirements. The results provide a scientific basis for further development of waste utilization technologies and improvements in road construction methods, which is particularly relevant given resource shortages and increasing environmental considerations in road construction materials.