The rapid growth of e-commerce has transformed how businesses operate globally, creating new opportunities but also introducing significant security challenges. As online platforms process millions of transactions daily, they face increasingly sophisticated cyber threats that can compromise customer data and disrupt business operations. Security management becomes particularly complex in the global marketplace. Organizations must navigate multiple regulations, such as the European Union’s General Data Protection Regulation (GDPR) and California’s Consumer Privacy Act (CCPA), which set strict standards for data protection and privacy. Additionally, supply chain security presents critical challenges, as demonstrated by recent breaches where attackers exploited vulnerabilities in vendor systems to access larger networks. This research analyzes current e-commerce security challenges and potential solutions. We examine how organizations implement established frameworks like the Payment Card Industry Data Security Standard (PCI DSS), while also adopting newer technologies such as advanced encryption, blockchain, and AI-based threat detection. Our findings indicate that while technological solutions are essential, they must be complemented by strong human factors - particularly staff training and security awareness, as human error remains a significant factor in security breaches. Based on empirical evidence and industry practices, we propose practical security recommendations. These include implementing Zero Trust Architecture to strengthen access controls, following international security standards for better compliance, and developing ethical data handling practices. Our research emphasizes the importance of regular security assessments to address emerging threats. The findings provide organizations with practical approaches to protect sensitive data and maintain customer trust. By implementing these recommendations, businesses can strengthen their security measures while building a foundation for sustainable growth in digital commerce.