The idea of quality of life maintains two measurement characteristics: one objective and the other subjective. The first can be measured through the material aspects available to a person or social group, such as private property, housing, land, access to basic services, secondary services, and leisure or entertainment services. Thus, the greater the access to these, the greater the quality of life. The second refers to psychological indicators such as happiness, satisfaction, and emotional well-being. However, since this study focuses on indigenous women, the aim here is to understand quality of life from a multidimensional perspective, seeking to avoid conceptual ethnocentrisms, as indigenous communities maintain an endogenous cosmogony and idiosyncrasy that is highly differentiated from those of large cities. Therefore, the aim is to understand the significance that indigenous women have on quality of life, also demonstrating that the life circumstances of the two groups of indigenous women studied maintain very marked asymmetries in their pursuit of well-being.