This chapter examines sex differences in the relationship between household configuration and life satisfaction in Mexico. Using data from the nationally representative ENBIARE 2021 survey, we employ ordinary least squares regression analyses to investigate how men and women differ in their reported life satisfaction across various household sizes and family configurations. Control variables include age, education level, and household assets. Our findings reveal significant sex-based differences in living arrangements. Men achieve the highest life satisfaction in relatively larger households, while women derive greater life satisfaction in smaller configurations. Women achieve greater life satisfaction from “couples without children” arrangements, whereas men report higher satisfaction in “couples with children” configurations, particularly when extended family is present. Both sexes experience reduced well-being in single-parent and single-person households. Domains-of-life analysis reveals these differences may be largely associated with gendered burdens and care responsibilities. Women’s satisfaction with economic situation and occupation is maximized in simpler family arrangements, while men benefit from larger, multi-generational households across most life domains. These findings highlight the importance of considering sex differences when designing family and labor policies, particularly those addressing unpaid care work distribution and social welfare access in Mexico.