How can societies respond effectively to environmental crises if they perceive nature and culture as separate, unrelated spheres? This chapter explores how the persistent conceptual dichotomy between nature and culture limits the social understanding of ecosocial problems and their impacts on human well-being. Through the case study of Celaya, in Mexico’s Laja-Bajio region, phenomena such as aquifer overexploitation and geological faults are analyzed as direct consequences of human actions that are socially perceived as isolated natural disasters. Grounded in an interdisciplinary framework that integrates Philosophy, History, and Psychology, and articulated through the paradigm of complex adaptive systems, this study demonstrates that ecological and social resilience are deeply interdependent. However, the fragmentation in social perception hinders the ability to recognize this interdependence, restricting the design of effective public policies and educational strategies. The chapter advocates for an ecosocial perspective on well-being and resilience that transcends economic growth paradigms and addresses the epistemological and cultural roots of the environmental crisis. Overcoming the nature/culture dichotomy is presented as essential for fostering sustainable development models and human flourishing.