Experimental investigations performed in the last four decades have shown that low-energy nuclear reactions (LENR) take place during electrolysis experiments. During these experiments, anomalous excess heat, emission of subatomic particles, such as neutrons and alpha particles, as well as appreciable variations in the chemical and isotopic compositions at the electrode surfaces were repeatably detected. Based on this experimental evidence and observing that micro- to macrocracks usually form at the electrode surfaces, it is assumed that LENR occur as fission reactions of the atomic nuclei lying on the electrode surfaces. Similarly to what done in the previous chapter, here we make use of the enhanced version of the Cook’s lattice model to study the fission of two chemical elements often employed as electrodes in electrochemical experiments, Ni and Pd. The results of the computations provide useful information on the expected fission-based transmutations of these elements and are commented in the light of experimental electrolysis data.