Water-mediated weathering is probably the main deterioration mechanism affecting compressed earth blocks (CEBs). Among the water-mediated mechanisms affecting the performance of CEBs in use, wind-driven rain, rising damp and alternating wetting and drying cycles are the most prominent ones. In this study, spray erosion and drip tests were first conducted in the lab to assess the effect of wind-driven rain on CEBs. Furthermore, capillary absorption experiments and wet/dry cycles were carried out to investigate their response against rising damp and alternating wetting and drying, respectively. The results of the laboratory tests showed that the CEBs under investigation were not severely affected in spray erosion and drip tests, while they presented a comparatively low capillary absorption coefficient. Furthermore, they were resistant to alternating wetting and drying cycles. Following the laboratory tests, wallettes using the same CEBs were built and exposed to real environmental conditions in a rural environment. The wallettes were built on a stone foundation to prevent them from being eroded due to direct contact with liquid water and the ground. The wallettes showed negligible erosion after an entire year of natural exposure. More specifically, no degradation was observed due to wind-driven rain, though localized erosion was evident in areas where surface run-off of water occurred. The results of this study show that there is an agreement between the laboratory tests and the natural exposure of CEB wallettes, thus suggesting that the CEBs under investigation may be used locally to build contemporary structures, without being in severe danger of water-mediated erosion.