This chapter analyzes the intricate relationship between financial stability and decentralized finance (DeFi). DeFi, a novel paradigm built on blockchain technology and self-executing smart contracts, aims to achieve disintermediation, transparency, and financial inclusion by removing centralized intermediaries. Key components include stablecoins (designed to mitigate volatility) and decentralized exchanges (DEXs). However, the permissionless architecture introduces a distinct matrix of technical, operational, and financial risks. Technical vulnerabilities, such as smart contract flaws and transaction attacks (e.g., front-running), are particularly substantial. Furthermore, many protocols exhibit a “decentralization illusion,” with centralized points of failure persisting in areas like governance, oracle dependence, and collateral management. These risks create channels for systemic instability, amplified by crypto assets’ high volatility and the lack of internal shock absorbers, which can lead to liquidity spirals and volatility spillovers to traditional financial markets. Real-world events, including the collapse of TerraUSD, underscore these dangers. Addressing these challenges requires robust and adaptive policy frameworks. International bodies (FSB, IMF) are pushing for consistent, granular global standards based on the “same business, same risk, same rule” principle, exemplified by the EU’s MiCA Regulation. The future of governance involves employing technologically informed approaches, such as embedded supervision and regulatory sandboxes, to balance innovation with critical oversight, consumer protection, and the mitigation of financial crime.