Headache disorders are among the most prevalent and disabling neurological conditions worldwide, yet they remain systematically neglected across personal, clinical, and policy domains. Migraine is the second leading cause of years lived with disability (YLDs) globally, while tension-type headache is the most common neurological disorder. Despite this burden, headaches are often trivialised, self-managed with over-the-counter medicines, or deprioritised by health systems compared with diseases associated with mortality. This chapter frames headaches as a global hindrance to achieving Sustainable Development Goal 3 (SDG-3) and examines three reinforcing layers of neglect. First, self-neglect: cultural norms and stigma normalise recurrent pain, deter care-seeking, and foster under-recognition, leading to chronification, medication overuse, and comorbid mental health conditions. Second, clinical neglect: inadequate education, misdiagnosis, fragmented pathways, inequitable access to triptans or preventives, and therapeutic inertia perpetuate disability and cost. Third, policy neglect: underinvestment in training, research, and service development magnifies inequities, particularly in low- and middle-income countries. Yet recent global advocacy demonstrates that this cycle can be broken. The 2019 World Brain Day on Migraine campaign showed that coordinated messaging can shift perceptions rapidly. The Genova Migraine Bill of Rights with WFNR reframed headache care as a matter of rights and equity. Annual World Migraine Day activities have mobilised communities worldwide, while the 2025 launch of the Parliamentary Brain Health Friendship Group in Australia and the KDU (Kotelawala Defence University, Sri Lanka) Brain Health Ambassador Program in Sri Lanka demonstrated how national advocacy and grassroots empowerment can reinforce global frameworks. Together, these initiatives show how local and global action can operationalise the WHO Intersectoral Global Action Plan (IGAP) and accelerate progress toward SDG-3. Overcoming headache-related hindrances is therefore not only a clinical duty but also a social, political, and moral imperative. By embedding headache into universal health coverage, ensuring equitable access to essential medicines, and investing in education and stigma reduction, societies can unlock immense health and economic gains, restore productivity, and improve quality of life for millions.