Migraine represents an escalating global public health challenge. Its burden, measured by prevalence, incidence, and DALYs, has significantly increased from 1990 to 2021 with reference to absolute numbers, with projections indicating a continued rise. This escalating burden is compounded by its profound socioeconomic impact, including substantial direct and indirect healthcare costs, and a pervasive negative effect on health-related quality of life and work productivity across all headache frequencies. The World Health Organization’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (WHOiGAP) provides a crucial strategic framework for addressing neurological disorders, including migraine. Its pillars are directly relevant to reducing migraine burden through improved policy, care, prevention, and research. Effectively addressing migraine is not merely a medical imperative but a critical economic and social necessity. Unmanaged migraine leads to considerable human suffering, lost productivity, and increased strain on healthcare systems. A coordinated global response, guided by the principles of WHOiGAP but with renewed commitment to its full and equitable implementation, is essential to mitigate this growing burden and improve global brain health.