Headache disorders, including migraine, tension-type headache, and cluster headache, affect over 3.5 billion individuals worldwide, causing substantial economic burden and social impairment. Despite their prevalence and impact, headache disorders remain neglected in global health agendas, contradicting the World Health Organization’s Sustainable Development Goals (SDGs), which emphasize health and well-being. The economic burden is significant, with estimated annual global costs exceeding $1.3 trillion, while socially, headache disorders impair productivity, relationships, and quality of life. Furthermore, healthcare disparities persist, with limited access to diagnosis, treatment, and care. To address these challenges, increased funding for headache research and education is crucial, alongside enhanced healthcare infrastructure and access, digital health tools, integrated care models addressing comorbidities, and policy reforms promoting workplace accommodations. By merging economic and social perspectives, we can reduce stigma, improve diagnosis, enhance treatment options and care, and foster inclusive, supportive communities. The SDGs offer a unique framework for addressing headache disorders, and we urge policymakers, healthcare professionals, and advocates to prioritize headache disorders, ensuring equitable access to care and promoting a healthier, more productive global society.