Antibiotic-resistant bacteria (ARB) have unique multiplication and survival capabilities against antibiotics, and they happen to be a global concern and threaten human health. Wastewater treatment plants are latent hotspots to propagate ARB, and controlling their dissemination in water calls for reliance on superior disinfection mechanisms since conventional technologies retain pathogens in filters, coagulants, or adsorbents, limiting complete disinfection. Practices demonstrating superior disinfection capabilities, such as nanotechnology in wastewater disinfection, membrane-based, electrochemical, and photocatalytic disinfection methods, and advanced oxidation process (AOP), are of interest in the present chapter. Innovative methods and significant progress are highlighted to address the emerging contaminants from hospitals, industries, and households. Investigations on integrated and hybrid disinfections are pointed out in the removal of emulsion polymers by a combined ultrasonic (US) and Fenton’s oxidation; photo-Fenton oxidation (PFO) and a two-dimensional nanodiamond (2D ND) of mixed nickel antimony-doped tin oxide (Ni-Sb-SnO2/ND-2) and another four-component metal oxide. Conversely, carbon nanotubes are a promising enhanced purification of diverse inorganic and organic contaminants in wastewater. This chapter is highlights the potential of advanced disinfection processes in addressing emerging pharmaceutical active compounds (PhACs), micropollutants, and pathogens in ordinary wastewater sources.