Industrial uses and commercial processes emit significant amounts of Cr into environment (soil, surface water, or atmosphere), leading to severe human health issues due to its toxicity. Biological Cr removal presents an alternative to conventional physicochemical approaches. This is regarded as a sustainable technology with reduced environmental effect. Microorganisms exhibiting resistance, like fungi, bacteria, alongside algae, have been primary focus of research about this characteristic. Microorganisms have developed various methods to mitigate chromium toxicity. These methods encompass bioaccumulation, biotransformation (oxidation/reduction), and/or biosorption, and are regarded as alternatives for heavy metal removal. Review objective is to summarize Cr(VI) bioremediation technology focused on practical applications at a wider scale. Salient findings of various studies concerning process feasibility and resilience of diverse systems (pilot scale and bioreactors) engineered for Cr-removal capability are emphasized.