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This paper presents new in vitro research on the biocompatibilityBiocompatibility of robotic microplasma-sprayed (MPS) hydroxyapatite (HA)Hydroxyapatite (HA) coatings applied to 3D-printed titanium scaffolds, comparing them to Ti6Al4V alloy treated by gas abrasion. The biocompatibilityBiocompatibility assessment included an Alamar Blue cell viability assay using rat bone marrow-derived mesenchymal stem cells, antibacterial testing against Escherichia coli (E. coli), and microstructural characterization using scanning electron microscopy (SEM). The results underscore the significant clinical potential of combining advanced digital manufacturing technologies—robotic MPS of HA coatings and selective laser melting for porous titanium scaffolds—to create orthopedic implants with bioactive, antibacterial, and biocompatible surfaces. The HA coatings demonstrated notably enhanced cell viability by 56%, improved cellular adhesion, and strong antibacterial effectiveness by reducing the E. coli growth by 30% after 15 hours, making them highly promising for orthopedic applications.

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Microplasma Spraying of Hydroxyapatite Coatings to Enhance Surface Bioactivity of 3D Printed Medical Titanium Implants

  • 会议论文

  • 发表日期：

    2026年

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  • Darya Alontseva,
  • Yuliya Safarova,
  • Bagdat Azamatov,
  • Sergii Voinarovych,
  • China Jesse Nwachukwu,
  • Alyona Russakova

摘要

This paper presents new in vitro research on the biocompatibilityBiocompatibility of robotic microplasma-sprayed (MPS) hydroxyapatite (HA)Hydroxyapatite (HA) coatings applied to 3D-printed titanium scaffolds, comparing them to Ti6Al4V alloy treated by gas abrasion. The biocompatibilityBiocompatibility assessment included an Alamar Blue cell viability assay using rat bone marrow-derived mesenchymal stem cells, antibacterial testing against Escherichia coli (E. coli), and microstructural characterization using scanning electron microscopy (SEM). The results underscore the significant clinical potential of combining advanced digital manufacturing technologies—robotic MPS of HA coatings and selective laser melting for porous titanium scaffolds—to create orthopedic implants with bioactive, antibacterial, and biocompatible surfaces. The HA coatings demonstrated notably enhanced cell viability by 56%, improved cellular adhesion, and strong antibacterial effectiveness by reducing the E. coli growth by 30% after 15 hours, making them highly promising for orthopedic applications.