This paper presents a novel integrative methodology for the simultaneous deactivation and detection of potentially hazardous substances, including energetic materials such as plastic explosivesExplosives and viral pathogens. The proposed approach synergistically combines prophylactic irradiation—effective in inactivating biological agents—with post-irradiation infrared (IR) thermographic analysis to identify anomalous thermal signatures. Deviations in temperature distribution, captured via high-resolution IR imaging, may indicate the presence of high-density, thermally reactive, or otherwise concealed materials. The core of the method relies on radiation-induced heatingRadiation–induced heating, which generates localized thermal responses in materials with distinct thermal capacities or conductivities. These responses are detected by high-sensitivity IR sensors fabricated using thin-film metal foils, which offer enhanced emissivity and rapid thermal transduction. By correlating these thermal anomalies with material-specific signatures, the system enables real-time screening and classification of suspect items. This multidisciplinary platform is designed for scalability and integration into high-throughput operational environmentsEnvironment, such as postal sorting facilities and cargo inspection hubs. It addresses a longstanding gap in security diagnostics by enhancing detection capabilities for low-contrastLow-contrast objects, non-metallic, and biologically active threats. The methodology represents a significant advancement in the development of hybrid detection systems that combine threat neutralization with passive sensing for comprehensive screening protocols.