The paper examines the cybersecurity challenges related to critical infrastructure dependencies in supply chains. It discusses how interconnected infrastructures, such as energy, healthcare, transportation, digital infrastructure, information and communication technologies, and government services, create vulnerabilities that cyberattacks can exploit. The study analyzes risks from digital threats, stolen digital certificates, compromised software development tools, and vendor fraud attacks. Using a threat dependency matrix, the paper assesses the impact of these threats across various sectors. The results highlight that financial services, healthcare, and ICT face the highest risks. At the same time, transportation and agriculture remain relatively less impacted. The findings emphasize the need for enhanced risk management strategies, supplier audits, and stronger regulatory frameworks to improve cybersecurity resilience.