The study of human evolution is a broad, multifaceted, and multisituated process that requires a critical approach. In this chapter, we will critically focus on the investigations into the first dispersals of humans in the Americas, which is considered one of the most recent episodes of global human expansions across the world. It consisted of the migration of Paleolithic human populations who moved from somewhere in Asia into the Americas, what has been coined as the “peopling of the Americas.” We argue that this research must be tackled not only from a scientific stance, but also through historical, epistemological, and geopolitical lenses. This means that a critical analysis of scientific hypothesis, interpretive methods, and empirical evidence becomes necessary to advancing and refining the science related to the evolutionary process of the human dispersal in the Americas. Therefore, besides the scientific critique of models and hypotheses, here we will discuss specifically a set of biases related to infrastructure, funding, and editorial industry, but overall, we will analyze the tradition of silencing or neglecting the research done by Latin American researchers from the hegemonic scientific mainstream. We claim that, in addition of the core scientific aspects, by taking into account a decolonial, multidisciplinary, multisituated, and polyphonic approach, it is possible to give some light on the differential circumstances of the research done by scholars from the Global North and those from the Global South, which resulted in an asymmetrical treatment to these different traditions of knowledge in the specialized literature. For instance, in the current literature, there is a misapprehension toward considering the morphometric and genetic uniparental data as obsolete methods for reconstructing human history. Furthermore, in such a context, the research done by scholars from Latin American countries and institutions is frequently neglected due to different reasons, even when it is frequently published in open access journals. Thus, we maintain that this multilayer analysis is important for the integration of scientific, historical, epistemological, and geopolitical elements as relevant issues of the scientific endeavor. In a nutshell, the “peopling of the Americas” is not just a scientific endeavor, but also a geopolitical matter.