The sericulture industry, which relies heavily on mulberry cultivation and silkworm rearing, islikely to face significant challenges in the near future due to the impacts of climate change. Rising temperatures, unpredictable weather patterns, and increased frequency of extreme events pose threats to the stability and productivity of sericulture. Biotechnology offers promising solutions to enhance the resilience of sericulture to these climate-induced stresses. This book chapter explores the implications of biotechnological advancements for developing climate-resilient sericulture practices. Key areas of focus include genetic modification and molecular breeding techniques to develop heat-tolerant and disease-resistant silkworm strains, as well as improving the quality and adaptability of mulberry plants and larvae of silkworm to changing environments. Additionally, biotechnological interventions in pest management, nutritional enhancements, and stress resistance are examined. The integration of these biotechnological approaches can lead to sustainable sericulture systems that are better equipped to withstand the impacts of climate change, ensuring consistent silk production and supporting the livelihoods of farmers dependent on this industry. This book chapter underscores the need for ongoing research and collaboration between scientists, industry stakeholders, and policymakers to fully realize the potential of biotechnology in securing the future of sericulture in a changing climate.